Sunday December 16th 2018

You're leaving and will be automatically redirected to

Go back to

Spice overdose: How much amount of Spice to OD?

Synthetic cannabinoids, also known as Spice or K2, are cannabinoid receptor agonists that target the same receptors in the brain as marijuana, but are not structurally related to marijuana. But can you really overdose on Spice?

Absolutely. Even one toke can provoke hallucinations or psychosis. What happens to the body during Spice intoxication with K2? How can you tell when you’ve smoked too much? Plus, can you die after smoking Spice? We review here. And then, we invite your questions about Spice and how you can treat Spice addiction or acute cases of overdose at the end.

How do unintentional Spice overdoses happen?

Accidental Spice overdose can happen to any individual, simply because the type and amount of cannabinoids in any batch of Spice can vary considerably. During a Spice overdose, severe psychiatric complications are likely to occur and can cause lasting changes to the brain.

Spice overdose – How much is too much?

The standard for production of Spice is unregulated, so content varies for different brands. Even within the same package, you may find excessive amount of THC-like content unevenly laced and sprayed on top of organic plant material. This means that there is no way to recommend or monitor Spice dosing at the moment. Therefore, how much Spice is too much Spice cannot be predicted.

Spice overdose complications

Synthetic cannabinoids, sold as Spice or K2, are cannabinoid receptor agonists are not structurally related to marijuana. The main purpose of Spice was to create a product that produced marijuana-like effects without using marijuana itself. However, Spice compounds many times greater potency (sometimes dozens or hundreds of time more potency) than the main psychoactive ingredient, THC, found in marijuana.

Compared to other illicit drugs, Spice can manifest effects similar to those experienced during opiate overdose such as nausea, vomiting and retching . However, when it comes to acute overdose, the symptoms are lot more extreme. Here is a list of the most common signs of Spice overdose.

  • agitation
  • anxiety
  • arrhythmia
  • diaphoresis (excessive sweating)
  • elevated blood pressure
  • elevated heart rate
  • hallucinations
  • palpitations
  • paranoid ideation
  • seizures
  • tachycardia
  • tremulousness

Spice overdose prognosis

When some experiences a case of mild overdose, the care consists of surveillance and support. But when it comes to severe toxicity with Spice, symptomatic treatment is practiced.

Like many other drugs, Spice is also highly addictive and develops certain level of tolerance in the body after continued chronic use. However, sudden discontinuation of use can cause withdrawal symptoms, such as profuse sweating, tremors, palpitations, insomnia, headache, depression, diarrhea, nausea, and vomiting. Withdrawal symptoms should be treated with benzodiazepines. Additionally, note that acute renal injury has been reported among teenagers after smoking a new synthetic cannabinoid referred to as XLR-11.

Spice overdose death rate

Fatalities, reported mainly as suicides, have been reported after use of a large mount of Spice, which is related to the psychotic episodes as overdose side effects. However, it is difficult to mortality rates related to Spice overdose simply because drug tests to recognize active psychoactive agents are not currently used in medical emergency room practice. However, suicidal behaviors and extreme violence are the most common fatalities after Spice use.

Spice overdose amount questions

Numbers of emergency room visits due to Spice overdose are up to 2000 patients a year nationwide in the U.S. The widespread availability of new varieties of synthetic cannabinoids makes the risk of future overdose more likely, as does slow government response to the epidemic.

Do you still have questions about Spice overdose or finding help for Spice addiction? In case we haven’t answered you, please feel free to post your specific Spice question in the following section. We will do our best in providing you with a prompt and personal answer.

Reference sources: ToxNet: Hazardous Substances Data Bank: Cannabicyclohexanol
FBI: Synthetic Marijuana
National Institute on Drug Abuse: Spice (synthetic marijuana)

Leave a Reply

14 Responses to “Spice overdose: How much amount of Spice to OD?
1:01 pm June 3rd, 2015

I explain quickly my story and after that I ask you some questions, i hope that you can give me answers.

So, my name is Vincent I’m 20 years old today, I’m french student in music. In fact, I smoked K2 3-4 times, but I suspect that I was do a overdose with this product. Now, I have depersonalization disorder, I am follow by one psychiatrist. At the beginning I took aplorazolam which are benzobiadepine and I took Omega-3 and i waiting to be cured, but it´s difficult to live my Life because of the symptoms. In France it´s difficult to have good answers about this subject because this drugs are not realy knows that why I hope that you can give me answers which can be good to me!

Now, questions Time:
How to cure depersonalization from K2? Like over depersonalization from other reason? (so follow psychotherapy? Take benzobiadepine?).
It´s possible to get better and get over this disorder?
Overdose with k2 it´s aggraver factor for depersonalization?
Which are the best therapies to get over this disorder?

I hope you can give me answers and thanks for your help!
And i am so sorry about my English which is so poor.
Thank you!

9:01 am March 27th, 2017

My son swallowed numerous balloons filled with k2 is now on a ventalater what can I expect to happen he was rushed to hospital with respiratory distress

11:50 pm July 6th, 2017

Why did the spice from early 2000’s did not effect people like how it does now before they banned it from it being legal is because it was just thc oils involved and why the big change after it was banned.

7:48 am August 29th, 2017

Spice will kill you period!

You are surely on the right path if you want to die

Have you ever thought about what it will do to the people that love?

Stop please

Sad Sister
7:29 am September 5th, 2017

My brother died last night from a spice overdose. Spice Kills! There were 7 people in the ER overdosed from spice when they took me to view my brother. 2 others also died before the night was over. He died getting high less than a block from his home! If you want to Die use Spice!

Lydia @ Addiction Blog
9:54 am September 5th, 2017

Hi Sad Sister. I’m really sorry for your loss…

9:25 pm December 3rd, 2017

I smoked a lot of k2 in the past I even o.d. Once it’s been almost 8 months since I last smoke and I will never do it again. I have memory lost real bad. My question is will my memory ever get better?

Lydia @ Addiction Blog
5:23 pm December 13th, 2017

Hi Lee. Maybe you’ll need to run some examination tests first.

Big Sister
7:53 pm January 13th, 2018

My brother is highly addicted to Spice. He has been for years. He started using it because he needed a job but didn’t want to give up smoking marijuana, & spice wasn’t detected in urine. Now, that’s all he does, literally all day. He is a completely different person & refuses to get help. I’ve tried everything I could, but California laws do not let me admit him into a rehabilitation center unless he chooses to do it himself, which he won’t because he doesn’t think he has a problem. He has overdosed a few times with seizures & episodes in front of younger siblings. My question is: does anyone know golf a way to force help on someone? Even when they refuse it? Police & Hospitals have done nothing for me… and I just want my little brother back.

Lydia @ Addiction Blog
3:25 pm January 18th, 2018

Hi Big Sister. I suggest you try staging an intervention with a professional. Search for an addiction interventionist in your area. Here are some useful links:

Also, take a look into the CRAFT model for families and interventions. One NGO called Allies in Recovery has some online reading that can help:

Denise, CASAC
9:12 pm May 21st, 2018

I am interested in knowing what the average cost is for treating a SPICE/K2 overdose in the Emergency Room.

Lydia @ Addiction Blog
11:07 am May 22nd, 2018
4:13 am September 19th, 2018

Is there anything that can reverse the effects of a spice overdose? Like narcan?

Lydia @ Addiction Blog
3:23 pm October 15th, 2018

Hi Cheryl. Currently, there is no antidote for Spice overdose, and clinical care typically only includes symptom management.

Leave a Reply