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When does ecstasy peak?

MDMA, short for 3,4-methylenedioxymethamphetamine, is most commonly known as “ecstasy” and/or “Molly.” It is a man-made drug that produces energizing effects similar to the stimulant class of amphetamines. But how serious can this effects of ecstasy become and what are the peak levels of ecstasy? You can find the answers to these questions in the text that follows. Then, we invite your questions in the comments section at the end.

What’s in ecstasy?

The main pyschoactive ingredient in ecstasy is 3,4-methylenedioxymethamphetamine, or MDMA, which is made of chemical variations of the stimulants amphetamine and methamphetamine. Ecstasy is a legal narcotic and can be mixed with a variety of other psychoactive drugs, most commonly hallucinogens like mescaline. MDMA is a “mood elevator” that produces a relaxed, euphoric state. ‘Black market’ ecstasy tablets vary widely in strength, and often contain other drugs.

The Cmax of ecstasy

Cmax is a term that refers to the maximum (or peak) serum concentration that a drug achieves in the body after it has been administrated. The main finding from research conducted on ecstasy is that while the MDMA dose is increased, the rise in MDMA concentrations does not follow proportionally, which could be indicative of non-linearity.

Ecstasy peak levels

For most people, a “hit” of MDMA lasts for 3 to 6 hours. Once an ecstasy pill is swallowed, it takes only about 15 minutes for MDMA to enter the bloodstream and reach the brain. About 45 minutes later, the person experiences MDMA’s “high.” That’s when the drug is at its peak level. People who use MDMA might feel very alert, or “hyper,” at first. Some lose a sense of time and experience other changes in perception, such as an enhanced sense of touch. Others experience negative effects right away.

Ecstasy ER, XR, CR peak levels

Ecstasy is not available in extended-release and long-acting form. It is most often available in tablet form and is usually ingested orally, although some users have reported taking it anally (known as “plugging” or “shafting”). Users have also been known to “parachute” the tablet, by placing the pill in a napkin, crushing it, and then swallowing the piece of napkin in an attempt to speed up the drug’s onset. MDMA is also available in powder form, often contained in gel tabs, and is sometimes snorted and occasionally smoked, but rarely injected.

Dangers of long term ecstasy use

Ecstasy users rarely talk about the negative effects of ecstasy on the brain. But they exist! Because MDMA produces long-term deficits in serotonin function, and because serotonin function has been implicated in the etiology of many psychiatric disorders including depression and anxiety, MDMA users may experience more psychopathology than non-users. Indeed, a number of investigators have found that heavy MDMA users experience a variety of psychiatric changes, scoring significantly higher on measures of obsessive traits, anxiety, paranoid thoughts, and disturbed sleep, among others.

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Furthermore, people who use MDMA can become dehydrated through vigorous activity in a hot environment. It may not seem like a big deal, but when MDMA interferes with the body’s ability to regulate its temperature, it can cause dangerous overheating, called hyperthermia. This, in turn, can lead to serious heart and kidney problems or, rarely, death. MDMA can also be extremely dangerous in high doses or when multiple small doses are taken within a short time period to maintain the high. High levels of the drug in the blood stream can increase the risk of seizures and affect the heart’s ability to maintain its normal rhythms.

How do I know if I’m addicted to ecstasy?

Researchers are still working to understand MDMA’s addictive properties. However, if you`re experiencing some of the symptoms included below, you may want to ask for help for ecstasy problems or consult a medical professional such as your family doctor, a psychologist, or a psychiatrist. The symptoms of addiction to any psychoactive drug include:

  • diminished recognition of significant problems with behaviors and relationships
  • drug craving
  • dysfunctional emotional response(s)
  • inability to consistently abstain from a drug
  • loss of control of drug use

Questions about peak times for ecstasy

Do you still have questions about ecstasy’s duration of action, onset, or peak levels? Please leave your questions or comments in the section below. We’ll do our vest to respond to you personally and promptly.

Reference Sources: NIDA: MDMA/Ecstasy Research: Advances, Challenges, Future Directions A Scientific Conference
NIDA for teens: MDMA (Ecstasy or Molly)
NHTSA: Methylenedioxymethamphetamine (MDMA, Ecstasy)
NCBI: Non-linear pharmacokinetics of MDMA (‘ecstasy’) in humans
NAU: Ecstasy/MDMA
Boston University Police
CESAR: Ecstasy

Photo credit: acespade999

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