What does cocaine do to the brain?

Cocaine interferes with the activity of the neurotransmitter, dopamine. It acts upon a part of the brain called the ventral tegmental area (VTA). More here on the chemistry behind the cocaine high.

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By Surya Solanki

Cocaine as a drug

Cocaine is produced from the leaves of the coca plant. The plant is cultivated in large quantities in South America. However, cocaine is an illicit drug and its production is a synthetic process. Coca leaves are mixed with an array of chemicals like sulfuric acid, kerosene, caustic soda and cement to produce a liquid, which is boiled to get “coka-paste” (solid form of cocaine).

Additionally, cocaine is a strong central nervous system (CNS) stimulant and causes a lot of activity in the brain. In this article, we look at the immediate effects of cocaine on the brain. Then, we invite your questions and feedback in the comments section at the end. In fact, we try to respond to all legitimate queries with a personal and prompt reply.

Cocaine and the brain

Inside the brain, cocaine acts upon a part of the brain called the ventral tegmental area (VTA). More specifically, cocaine interferes with the activity of the dopamine neurotransmitter. How?

Neurotransmitters are used by neurons to communicate. Dopamine acts both as an inhibitory and excitatory neurotransmitter- so it may rev up the speed of the electrical impulses in the neuron or reduce it. But the behavior of dopamine chemicals depend on the receptors they encounter. If the dopamine chemicals attach to the “feel good” chemical in reward pathway of the brain, we feel pleasurable. Similarly, dopamine can also trigger neurons that produce a feeling of panic or ones that cause impulsive behavior.

Normally, dopamine is re-absorbed via the dopamine transporter by the neuron that produced it. However, cocaine blocks the transporter. As a result, dopamine starts building up. In fact, cocaine blocks 60-77% of dopamine transporters in the central nervous system. And on average, in order to maintain a high, 47 sites must be blocked.

Additionally, cocaine also alters the level of serotonin (the neurotransmitter responsible for maintaining mood balance) in our brains. Even more, cocaine increases the amount of norepinephrine, which controls the body flight and fight response. Hence, the following effects of cocaine:

  • increased blood pressure
  • increased body temperature
  • increased heart rate
  • increased rate of respiration

The effect of cocaine varies

Depending upon the sites it blocks, the user experience may feel euphoric, paranoid, impulsive or talkative. This effect varies. While Sigmund Freud took cocaine in “small doses” to battle depression, large amounts of cocaine have been linked to the development of extreme paranoia, or even schizophrenia (the latter is linked with high levels of dopamine).

Method of administration

How quickly cocaine reaches the brain depends on the method of drug administration. Powder cocaine is usually snorted or injected. When snorted, the drug takes about three minutes to reach the brain. Whereas, when powder cocaine is injected into the veins, it takes about 14 seconds to reach the brain. When cocaine is smoked, it reaches the brain in seven seconds. Does cocaine work for everyone? Yes, usually it has a stimulant effect on all users, although euphoric effect can be subjective.

Are there differences between crack and powder cocaine?

Contrary to popular belief, crack cocaine and powder cocaine are the same drug. They have the “same biological effect” but differ in “chemical composition”. Powder cocaine contains hydrochloride salt, which prevents it from being burned. This salt can be removed by mixing the cocaine with water or baking soda. The resultant chemical so formed is called “crack cocaine”. Crack has a lower melting point (90 degree Celsius) than powder cocaine  (180 degree Celsius) and hence, can be smoked. The name “crack” is derived from the sound the drug makes while being smoked.

Brain withdrawal after the high

Another characteristic of cocaine is that the body goes through immediate drug withdrawal, even after one use. A cocaine high may last for up to an hour (depending on the quality of the drug). When the effects of cocaine start to wane, dopamine levels become normal but can be experienced as a deficit. As a result, the main cocaine withdrawal side effect is that the user may feel “low” for a bit.

Continual use of cocaine is an artificial way of increasing dopamine and serotonin. Soon, the brain becomes rewired to produce less and less of the two chemicals and starts relying on cocaine to produce them. In this case, when the user stops doing cocaine, s/he faces depression, anxiety and other problems linked with serotonin and dopamine deficiency.

Cocaine and brain addiction

Although cocaine blocks dopamine chemicals in the synapse, after a period of time, the dopamine breaks down. Now the stock of dopamine needs to be replenished. Otherwise the user will feel depressed and “low”. The natural process of dopamine replenishment takes time. As a result, the user starts craving the drug. This is how addiction starts.

Questions about cocaine and the brain?

Do you still have questions about how cocaine acts on the brain? Please leave your questions below. We’ll do our best to respond to you personally and promptly.

Reference Sources: TSRI
US National Library of Medicine
National Institute of Drug Abuse
About the author
Lee Weber is a published author, medical writer, and woman in long-term recovery from addiction. Her latest book, The Definitive Guide to Addiction Interventions is set to reach university bookstores in early 2019.


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  1. I question that cocaine will destroy brain cell which would inhabit the human from learning.I know for a fact, a man received a BA college with a GPA of 3.0.
    This is a fact through observation.
    Another fact, cocaine improves depression from the effect of PTSD. This also was an observation
    I agree that dopamine will cause a build in the electricity of the brain that will impair the motor skills but it is not an addictive drug, it is a mental engine for pleasure. It does not cause angry, That is in that person’s personality or character. Cocaine is a big sexual bold performer. It will bring the bold acts out of a perform, exhibitionist .common phase, no shame in my game. Most of all it will cause the joy of oral sex out of a person, male or female even the person is heterosexual., this is a strong desire of a straight male because he wondered about it.

  2. One week I went on a 3 day binge. Drinking All 3 days and on the 3rd day in the afternoon started using cocaine up until almost midnight while still drinking. Went to sleep fine that night. Woke up feeling horrible. Thought it was just another hangover til the following day I still felt the same but w/ a great deal of remorse and regret for what I’ve done. Depression was setting in bad. I figured if I hit up the gym and get a good work out in and sweat all the bad out I’ll be ok. I was fine for a little while after the gym and the depression crept up on me again. The feeling lingered around for about a week (worst week of my life) each day slowly getting better. What helped me I think was working out. Drinking lots of water. And fish oil. Not sure how much that helped but I read it’s good for helping your brain recover. Just wanted to write on the subject to let people know there is a light at the end of the tunnel. It doesnt seem that way. Seems like it’s never gonna end but it does. Just stay strong.

  3. I was experimenting with drugs when I was in college. I started to get really bad anxiety, which then would put me in a deep depression. I never did too much. I’ve seen people do way more and still be okay. Up until about a week ago, I hadn’t touched a drug in almost two years. Those two years were absolutely miserable. Intense lows with severe anxiety and depression. I would wake up in the mornings and my head was just spinning. This went on for about a year before I went to see a doctor. The doctor prescribed me lexipro and it helped, but not enough. I was still tired ALL THE TIME. I don’t know if it was the drugs that made me this way or if it was just something that I was going to get no matter what. I’m trying to get my doctor to prescribe me to some type of stimulant like adderol. But, the process takes a while. I need to get my school work done, so I turn to coke when I don’t have an adderoll. Even though the coke sometimes gives me a little anxiety, I still feel way better than when I dont use it. Any advice?/??

  4. This type of illnes such addiction although you need other people to support but the willingness have to come from themself not because s/he is your siblings or spouse. Most of drug users now the effect anyway but they stil using it until the last penny. I left my boyfriend because annoying when he ask me to buy chocolate for one or two pounds but can spent the entire salary for cocaine. Now he list his job, his beauty, his dignity and soon maybe his life ! So never never ever touch drugs !!

  5. Well cocaine is included of what we called illegal drug\s and we should know the consequences once a person get addicted to it. It may harm and damage their brain. A person who is using cocaine becomes delusional and is running away from the reality of the world. A drug treatment center should always explain this to the patients and to the families and friends in order to prevent more people that will be engaged in using such drugs that later on it will lead them to insanity…

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