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Cocaine

2 Adverse effects of cocaine (INFOGRAPHIC)

Adverse effects of cocaine (INFOGRAPHIC)

April 1st, 2015

What are the adverse effects of cocaine? Check out this infographic for a visual story. If you like it, we invite you to print it out as a poster or share it with your friends!

16 Long term effects of cocaine on the brain (INFOGRAPHIC)

Long term effects of cocaine on the brain (INFOGRAPHIC)

February 22nd, 2015

Are you interested in the effects of cocaine on the brain? Check out this infographic! Then, LIKE > SHARE > PRINT it out. We invite you to use the graphic in your school or medical practice!

3 What does cocaine do to the brain?

What does cocaine do to the brain?

January 27th, 2015

Cocaine interferes with the activity of the neurotransmitter, dopamine. It acts upon a part of the brain called the ventral tegmental area (VTA). More here on the chemistry behind the cocaine high.

2 Cocaine withdrawal side effects

Cocaine withdrawal side effects

January 15th, 2015

What happens to the body and mind when you stop taking cocaine? A review of primary and secondary side effects during cocaine withdrawal here.

2 Cocaine withdrawal signs

Cocaine withdrawal signs

January 4th, 2015

Signs of cocaine withdrawal include a “crash” period of fatigue, dysphoria, and decreased interest followed by changes in mood and possible mood disorders. More on cocaine withdrawal and its signs here.

Long term effects of cocaine on pregnancy (INFOGRAPHIC)

Long term effects of cocaine on pregnancy (INFOGRAPHIC)

December 16th, 2014

Does cocaine negatively affect sexuality? You bet it does. Find out how cocaine use affects sex, reproduction, and early childhood here.

2 Cocaine effects

Cocaine effects

December 12th, 2014

What are the systemic effects of cocaine on your body and mind? We explore in-depth here.

10 Adverse effects of cocaine on the brain (INFOGRAPHIC)

Adverse effects of cocaine on the brain (INFOGRAPHIC)

November 25th, 2014

Does cocaine affect the brain? How? Check out this visual graphic to find out. If you like it, please SHARE with your friends or start a discussion here.

3 Is cocaine a narcotic?

Is cocaine a narcotic?

November 22nd, 2014

In the U.S., cocaine is legally a narcotic. Medically, it is not. More on the classification of cocaine under the Controlled Substances Act here.

108 Cocaine detox timeline: How long to detox from cocaine?

Cocaine detox timeline: How long to detox from cocaine?

September 28th, 2014

It takes a little under a week to recover from the acute effects of a cocaine binge. What can you expect during this time? We review a common timeline of cocaine detox effects here.

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Cocaine

What is cocaine?

Cocaine is a drug obtained from the leaves of coca plant (Erythroxylum Coca). Pure cocaine has a chemical formula C17H21NO4. Cocaine can be smoked, consumed orally, inhaled or administered using suppositories.

Cocaine appears in several forms, but pure cocaine is a white and pearly powder. Cocaine can also exist as crack cocaine, a freebase form of cocaine containing baking soda and other impurities. Cocaine also appears in a liquid form as cocaine hydrochloride for medical use. The amount of cocaine found in any form varies largely by dealer.

Cocaine is also known by names such as Barbs, Blow, Coke, Dream, Foo-foo dust, Her, King’s habit, Peruvian lady and Snow. Crack cocaine is also known in the streets as Crack, Rock, Iron, Cavvy, Beam, Bopper, Candy, CDs, Electric kool-aid, Girl, Mighty white, Pop, Real tops, Rock, SevenUp, Space, Twinkie and Yam.

How is cocaine made?

To make cocaine, coca leaves are processed by soaking them in water with lime to release the alkaloids. Then, a solvent such as kerosene or diesel is added to the mixture to recover alkaloids and then dried to make a paste. Chemicals like ether and sulfuric acid are then added into the paste to increase purity and create cocaine hydrochloride. It takes 100 to 150 kilos of dry coca leaves to make a kilo of cocaine paste, and it’s a bit amazing that this process is still used by clandestine labs to make several tons a day.

Cocaine effects

Cocaine is a stimulant – the most powerful stimulant found in nature. In general, cocaine has an uncontrolled stimulating effect in the body. The effects of cocaine soon after administration are called a “high”. Snorting or injecting cocaine can produce a high sooner than other routes of administration. Common effects of cocaine include:

  • raised blood pressure
  • raised heart rate
  • spikes in brain activity

Cocaine’s mechanism of action

Cocaine easily crosses the blood-brain barrier (one of the few drugs able to do so) and enters the brain where it immediately interacts by stimulating the neurotransmitter dopamine. In fact, cocaine works by overstimulation of the receptors on the postsynaptic neuron of a brain nerve, either by increasing the amount of dopamine in the synapse through excessive presynaptic release or by inhibiting dopamine’s pattern of reuptake or chemical breakdown. Because the receptors are stimulated for an extended period of time, the user experiences elevated mood, less fatigue, more energy and strength and restlessness.

Cocaine overdose

The main problem with cocaine is that it causes unpredictable constriction of blood vessels in the body, causing reduced or loss of supply of blood to vital organs like the kidneys, liver, brain and heart. Cocaine overdose can lead to organ damage or stroke. In addition, high amounts of cocaine can exert intense stimulation to brain cells that cause abnormally high spikes of electrical activity and result to life-threatening seizures.

Anyone who uses cocaine can experience overdose because the purity of street-brought drug can fluctuate wildly. Here are signs and symptoms of cocaine overdose:

  • breathing difficulties; gasping breath, or irregular breathing
  • coldness of the hands, feet and body core (hypothermia)
  • heart beat irregularities; heart rate too fast, weak or out of rhythm
  • high blood pressure, heart failure and heart attack
  • incontinence
  • loss of consciousness and passing out
  • seizures

Cocaine naive users can experience overdose even from a small amount of high-purity cocaine. The threat of cocaine overdose is multiplied when other drugs like methamphetamine and alcohol are used concurrently. Cocaine overdose can easily proceed to life-threatening situation, so immediate medical help is necessary. A person overdosed with cocaine can die from heart attack, shock or organ failure.

If you happen to find a person with signs and symptoms of cocaine overdose, call 911 or contact poison control center immediately. Do not give any water, coffee or any liquid to the victim. Try to keep him or her awake. Do not leave the victim, and follow instructions of the medical professional on the end of the line. If the victim is unconscious and has no breathing or heartbeat, you or others may need to perform emergency CPR (cardiopulmonary resuscitation) until paramedics arrive. In case the victim has seizures, do not try to hold him or put a towel in his mouth. Just clear the area to avoid the victim from hurting himself, and put him in the recovery position to reduce risk of choking in case he vomits.

For more information on cocaine, see:

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